BIS2 co-evolution analysis of DENV envelope glycoproteins


Here we provide the files used and produced in our co-evolution analysis performed on the envelope glycoproteins E and PrM of the Dengue Virus (DENV), serotype 2.


Each folder contains the results of the co-evolution analysis performed with BIS2:

Note that the order of the clusters in the article (see below) and in the files provided in this webpage might differ. Please be aware of this when referring to cluster's IDs.



For questions, comments, or suggestions on BIS/BIS2 co-evolution analysis, feel free to contact Alessandra Carbone or Francesca Nadalin.

For questions, comments, or suggestions regarding DENV biology, feel free to contact Dimitri Lavillette or Florian Douam.



The results reported in this webpage are described in the following article:

  • F. Douam, et al. A protein coevolution method uncovers critical features of the Hepatitis C Virus fusion mechanism. (under review)

The description of BIS/BIS2 co-evolution method can be found in the following articles:


Last Update October 2017