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Genomic Physics


The Genophysique (Genomic Physics) group combines tools from theoretical physics (statistical mechanics, soft condensed matter, hydrodynamics), to study biological questions concerning genomes and the cells that carry them. We favor a bottom-up approach where simple models are gradually constructed from data analysis and experiments.

One of the main questions we are focusing on is how bacteria compute patterns of active genes in response to stimuli and cues using both the specific chemical binding of specialized proteins (the "regulatory network") and the physical organization of the bacterial genome as a complex polymer. We also study the architecture and evolution of regulatory networks, quantitative descriptions of bacterial growth, and the laws that determine the partitioning of genomes into functional and evolutionary elements.

Selected Publications
Scolari VF, Cosentino Lagomarsino M.
Combined collapse by bridging and self-adhesion in a prototypical polymer model inspired by the bacterial nucleoid.
Soft Matter. 11, pp.1677-1687 (2015).
Zamparo M, Chianale F, Tebaldi C, Cosentino Lagomarsino M, Nicodemi M, Gamba A.
Dynamic membrane patterning, signal localization and polarity in living cells.
Soft matter. 11, pp.838–849 (2015).
Osella M, Nugent E, Cosentino Lagomarsino M.
Concerted control of Escherichia coli cell division.
Proc Natl Acad Sci U S A. 111(9), pp.3431-5 (2014).
Javer A, Kuwada NJ, Long Z, Benza VG, Dorfman KD, Wiggins PA, Cicuta P, Cosentino Lagomarsino M.
Persistent super-diffusive motion of Escherichia coli chromosomal loci.
Nat Commun. 5, pp.3854 (2014).
Javer A, Long Z, Nugent E, Grisi M, Siriwatwetchakul K, Dorfman KD, Cicuta P, Cosentino Lagomarsino M.
Short-time movement of E. coli chromosomal loci depends on coordinate and subcellular localization.
Nat Commun. 4, pp.3003 (2013).
Grilli J, Bassetti B, Maslov S, Cosentino Lagomarsino M.
Joint scaling laws in functional and evolutionary categories in prokaryotic genomes.
Nucleic Acids Res. 40(2), pp.530-40 (2012).
Scolari VF, Zarei M, Osella M, Cosentino Lagomarsino M.
NuST: analysis of the interplay between nucleoid organization and gene expression.
Bioinformatics. 28(12), pp.1643-4 (2012).
Benza VG, Bassetti B, Dorfman KD, Scolari VF, Bromek K, Cicuta P, Cosentino Lagomarsino M.
Physical descriptions of the bacterial nucleoid at large scales, and their biological implications.
Rep Prog Phys. 75(7), pp.076602 (2012).

Open Positions