LISA: Local Interaction Signal Analysis
A protein-protein binding affinity estimation software
LISA is an empirical scoring function that estimates the binding affinity between two proteins, given the 3D structure of their complex. LISA provides a fine description of the spatial distribution of favorable and unfavorable contacts on the interacting surface. It achieves a correlation of 0.81 on 125 complexes whose binding affinities were experimentally measured with selected reliable technologies. LISA compares favorably with 17 other state-of-the-art functions.
The LISA package is available here.
- UNIX platform (Linux/OSX) and a GCC compiler.
- Uncompress the LISA_1.0.tgz archive in the directory of your choice.
- Follow the instructions in the README to install the required dependencies.
- Run the executable $LISA_PATH/LISA-1.0.py on the example input files (see TEST_commands.txt).
The LISA package has been developed under the CeCILL licence (see LICENCE).
If you use LISA, please cite: