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adabmDCA: adaptive Boltzmann machine learning for biological sequences

TitleadabmDCA: adaptive Boltzmann machine learning for biological sequences
Publication TypeJournal Article
Year of Publication2021
AuthorsMuntoni, AP, Pagnani, A, Weigt, M, Zamponi, F
JournalBMC Bioinformatics
Date Published2021/10/29
ISBN Number1471-2105

Boltzmann machines are energy-based models that have been shown to provide an accurate statistical description of domains of evolutionary-related protein and RNA families. They are parametrized in terms of local biases accounting for residue conservation, and pairwise terms to model epistatic coevolution between residues. From the model parameters, it is possible to extract an accurate prediction of the three-dimensional contact map of the target domain. More recently, the accuracy of these models has been also assessed in terms of their ability in predicting mutational effects and generating in silico functional sequences.

Short TitleBMC Bioinformatics