You are here

Amphiphilic four-helix bundle peptides designed for light-induced electron transfer across a soft interface.

TitleAmphiphilic four-helix bundle peptides designed for light-induced electron transfer across a soft interface.
Publication TypeJournal Article
Year of Publication2005
AuthorsYe, S, Discher, BM, Strzalka, J, Xu, T, Wu, SP, Noy, D, Kuzmenko, I, Gog, T, Therien, MJ, P Dutton, L, J Blasie, K
JournalNano Lett
Volume5
Issue9
Pagination1658-67
Date Published2005 Sep
ISSN1530-6984
KeywordsAmino Acid Sequence, Drug Design, Electron Transport, Models, Molecular, Molecular Sequence Data, Nanostructures, Nanotechnology, Peptides, Protein Structure, Secondary, Static Electricity, X-Ray Diffraction
Abstract

A family of four-helix bundle peptides were designed to be amphiphilic, possessing distinct hydrophilic and hydrophobic domains along the length of the bundle's exterior. This facilitates their vectorial insertion across a soft interface between polar and nonpolar media. Their design also now provides for selective incorporation of electron donor and acceptor cofactors within each domain. This allows translation of the designed intramolecular electron transfer along the bundle axis into a macroscopic charge separation across the interface.

DOI10.1021/nl050542k
Alternate JournalNano Lett.
PubMed ID16159202
Grant ListGM071628 / GM / NIGMS NIH HHS / United States
GM41048 / GM / NIGMS NIH HHS / United States
GM48130 / GM / NIGMS NIH HHS / United States
GM55876 / GM / NIGMS NIH HHS / United States
GM63388 / GM / NIGMS NIH HHS / United States
RR14812 / RR / NCRR NIH HHS / United States