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Chromosome mobility and genome integrity:what we are learning from budding yeast

Thursday, June 29, 2017 - 11:00
Emmanuelle Fabre
LCQB Kitchen, Campus Jussieu, Bâtiment C 4e étage 4 place Jussieu, 75005 PARIS
Hopital St Louis, UMR7212 CNRS – U 944 INSERM

Dynamic chromosome organization is not random and plays a role in genome expression and integrity. Our discoveries have collectively contributed to the current understanding of the principles of yeast chromosome organization and their functional role towards the repair of a double stranded DNA break (DSB) (Berger et al., NM 2008; Therizols et al., PNAS 2010; Zimmer and Fabre ,JCB 2011; Brickner et al., GD 2012; Agmon et al., NCB 2013).  Further, chromosome motion is required for Homologous recombination to occur. I will present recent work on the role of actin and cytoskeleton connections with the nucleopore in subtelomeres movement and DSB repair (Spichal et al. JCS 2016). In addition to motion induced by actin, I will present recent discoveries on the role of chromatin physical properties in chromosome mobility upon random DNA damage. 

Genomics Seminar

Open Positions