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Coevolution analysis of Hepatitis C virus genome to identify the structural and functional dependency network of viral proteins.

TitleCoevolution analysis of Hepatitis C virus genome to identify the structural and functional dependency network of viral proteins.
Publication TypeJournal Article
Year of Publication2016
AuthorsChampeimont, R, Laine, E, Hu, S-W, Penin, F, Carbone, A
JournalScientific Reports
Volume6
Date Published05/2016
Abstract

A novel computational approach of coevolution analysis allowed us to reconstruct the protein-protein interaction network of the Hepatitis C Virus (HCV) at the residue resolution. For the first time, coevolution analysis of an entire viral genome was realized, based on a limited set of protein sequences with high sequence identity within genotypes. The identified coevolving residues constitute highly relevant predictions of protein-protein interactions for further experimental identification of HCV protein complexes. The method can be used to analyse other viral genomes and to predict the associated protein interaction networks.

 

 

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