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DiNAMO: highly sensitive DNA motif discovery in high-throughput sequencing data

TitleDiNAMO: highly sensitive DNA motif discovery in high-throughput sequencing data
Publication TypeJournal Article
Year of Publication2018
AuthorsSaad, C, Noé, L, Richard, H, Leclerc, J, Buisine, M-P, Touzet, H, Figeac, M
Volume19
Issue1
Pagination223
Date Published2018/06/11
ISBN Number1471-2105
Abstract

Discovering over-represented approximate motifs in DNA sequences is an essential part of bioinformatics. This topic has been studied extensively because of the increasing number of potential applications. However, it remains a difficult challenge, especially with the huge quantity of data generated by high throughput sequencing technologies. To overcome this problem, existing tools use greedy algorithms and probabilistic approaches to find motifs in reasonable time. Nevertheless these approaches lack sensitivity and have difficulties coping with rare and subtle motifs.

URLhttps://doi.org/10.1186/s12859-018-2215-1
Short TitleBMC Bioinformatics