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Effects of initial telomere length distribution on senescence onset and heterogeneity.

TitleEffects of initial telomere length distribution on senescence onset and heterogeneity.
Publication TypeJournal Article
Year of Publication2017
AuthorsEugène, S, Bourgeron, T, Xu, Z
JournalJ Theor Biol
Volume413
Pagination58-65
Date Published2017 Jan 21
ISSN1095-8541
KeywordsCellular Senescence, Computer Simulation, DNA Replication, Evolution, Molecular, Numerical Analysis, Computer-Assisted, Telomerase, Telomere, Telomere Homeostasis
Abstract

Replicative senescence, induced by telomere shortening, exhibits considerable asynchrony and heterogeneity, the origins of which remain unclear. Here, we formally study how telomere shortening mechanisms impact on senescence kinetics and define two regimes of senescence, depending on the initial telomere length variance. We provide analytical solutions to the model, highlighting a non-linear relationship between senescence onset and initial telomere length distribution. This study reveals the complexity of the collective behavior of telomeres as they shorten, leading to senescence heterogeneity.

DOI10.1016/j.jtbi.2016.11.010
Alternate JournalJ. Theor. Biol.
PubMed ID27864096
PubMed Central IDPMC5177728