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The evolution of the temporal program of genome replication.

TitleThe evolution of the temporal program of genome replication.
Publication TypeJournal Article
Year of Publication2018
AuthorsAgier, N, Delmas, S, Zhang, Q, Fleiss, A, Jaszczyszyn, Y, van Dijk, E, Thermes, C, Weigt, M, Cosentino Lagomarsino, M, Fischer, G
JournalNat Commun
Volume9
Issue1
Pagination2199
Date Published2018 Jun 06
ISSN2041-1723
Abstract

Genome replication is highly regulated in time and space, but the rules governing the remodeling of these programs during evolution remain largely unknown. We generated genome-wide replication timing profiles for ten Lachancea yeasts, covering a continuous evolutionary range from closely related to more divergent species. We show that replication programs primarily evolve through a highly dynamic evolutionary renewal of the cohort of active replication origins. We found that gained origins appear with low activity yet become more efficient and fire earlier as they evolutionarily age. By contrast, origins that are lost comprise the complete range of firing strength. Additionally, they preferentially occur in close vicinity to strong origins. Interestingly, despite high evolutionary turnover, active replication origins remain regularly spaced along chromosomes in all species, suggesting that origin distribution is optimized to limit large inter-origin intervals. We propose a model on the evolutionary birth, death, and conservation of active replication origins.

DOI10.1038/s41467-018-04628-4
Alternate JournalNat Commun
PubMed ID29875360