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Inter-residue, inter-protein and inter-family coevolution: bridging the scales.

TitleInter-residue, inter-protein and inter-family coevolution: bridging the scales.
Publication TypeJournal Article
Year of Publication2017
AuthorsSzurmant, H, Weigt, M
JournalCurr Opin Struct Biol
Volume50
Pagination26-32
Date Published2017 Nov 01
ISSN1879-033X
Abstract

Interacting proteins coevolve at multiple but interconnected scales, from the residue-residue over the protein-protein up to the family-family level. The recent accumulation of enormous amounts of sequence data allows for the development of novel, data-driven computational approaches. Notably, these approaches can bridge scales within a single statistical framework. Although being currently applied mostly to isolated problems on single scales, their immense potential for an evolutionary informed, structural systems biology is steadily emerging.

DOI10.1016/j.sbi.2017.10.014
Alternate JournalCurr. Opin. Struct. Biol.
PubMed ID29101847