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Protein S-nitrosylation in photosynthetic organisms: A comprehensive overview with future perspectives

TitleProtein S-nitrosylation in photosynthetic organisms: A comprehensive overview with future perspectives
Publication TypeJournal Article
Year of Publication2016
AuthorsZaffagnini, M, De Mia, M, Morisse, S, Di Giacinto, N, Marchand, CH, Maes, A, Lemaire, SD, Trost, P
JournalBiochim Biophys Acta
Volume1864
Pagination952-66
Date PublishedAug
ISBN Number0006-3002 (Print)0006-3002 (Linking)
KeywordsArginine/genetics/metabolism, Nitric Oxide/genetics/*metabolism, Nitrites/metabolism, Plant Proteins/genetics/*metabolism, Plants/genetics/*metabolism, Protein Processing, Post-Translational/*physiology, Proteomics/*methods
Abstract

BACKGROUND: The free radical nitric oxide (NO) and derivative reactive nitrogen species (RNS) play essential roles in cellular redox regulation mainly through protein S-nitrosylation, a redox post-translational modification in which specific cysteines are converted to nitrosothiols. SCOPE OF VIEW: This review aims to discuss the current state of knowledge, as well as future perspectives, regarding protein S-nitrosylation in photosynthetic organisms. MAJOR CONCLUSIONS: NO, synthesized by plants from different sources (nitrite, arginine), provides directly or indirectly the nitroso moiety of nitrosothiols. Biosynthesis, reactivity and scavenging systems of NO/RNS, determine the NO-based signaling including the rate of protein nitrosylation. Denitrosylation reactions compete with nitrosylation in setting the levels of nitrosylated proteins in vivo. GENERAL SIGNIFICANCE: Based on a combination of proteomic, biochemical and genetic approaches, protein nitrosylation is emerging as a pervasive player in cell signaling networks. Specificity of protein nitrosylation and integration among different post-translational modifications are among the major challenges for future experimental studies in the redox biology field. This article is part of a Special Issue entitled: Plant Proteomics--a bridge between fundamental processes and crop production, edited by Dr. Hans-Peter Mock.

URLhttp://www.ncbi.nlm.nih.gov/pubmed/26861774
Short TitleBiochimica et biophysica acta