You are here

SPA: Simple web tool to assess statistical significance of DNA patterns.

TitleSPA: Simple web tool to assess statistical significance of DNA patterns.
Publication TypeJournal Article
Year of Publication2003
AuthorsRichard, H, Nuel, G
JournalNucleic Acids Res
Volume31
Issue13
Pagination3679-81
Date Published2003 Jul 1
ISSN1362-4962
KeywordsData Interpretation, Statistical, Internet, Markov Chains, Regulatory Sequences, Nucleic Acid, Sequence Analysis, DNA, Software, User-Computer Interface
Abstract

Many statistical methods and programs are available to compute the significance of a given DNA pattern in a genome sequence. In this paper, after outlining the mathematical background of this problem, we present SPA (Statistic for PAtterns), an expert system with a simple web interface designed to be applied to two of these methods (large deviation approximations and exact computations using simple recurrences). A few results are presented, leading to a comparison between the two methods and to a simple decision rule in the choice of that to be used. Finally, future developments of SPA are discussed. This tool is available at the following address: http://stat.genopole.cnrs.fr/SPA/.

Alternate JournalNucleic Acids Res.
PubMed ID12824392
PubMed Central IDPMC169190