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Transcriptomes, transcription activators and microarrays.

TitleTranscriptomes, transcription activators and microarrays.
Publication TypeJournal Article
Year of Publication2001
AuthorsDevaux, F, Marc, P, Jacq, C
JournalFEBS Lett
Volume498
Issue2-3
Pagination140-4
Date Published2001 Jun 8
ISSN0014-5793
KeywordsDatabases, Factual, Gene Expression Profiling, Oligonucleotide Array Sequence Analysis, Saccharomyces cerevisiae, Transcription Factors, Transcription, Genetic
Abstract

Gene-specific transcription activators are among the main factors which specifically shape the transcriptome profiles. It is tempting to take advantage of their properties to decipher the genome expression circuitry. The advent of microarray technology has offered fantastic opportunities to quickly analyze the expression profiles dictated by specific transcription factors. This review will first focus on the strategies which have been devised to control the activity of transcription factors and in the second part on the microarray experiments which addressed the role of these transcription factors in the genome-wide expression profile. This last part will mainly consider the case of the yeast Saccharomyces cerevisiae genome. All the collected data are available through the on-line database yTAFNET (http://transcriptome.ens.fr/ytafnet/). yTAFNET is designed to help the characterization of connections between the different yeast regulatory networks.

Alternate JournalFEBS Lett.
PubMed ID11412845