I develop computational approaches to help the design of biological intervention improving human health. I have contributed to methods for predicting protein interfaces and binding affinities, for identifying protein cellular partners and describe the protein « sociability », for predicting conformational transitions, for predicting mutational outcomes at large scale, and for rationalizing the propagation of mutational effects across protein structures. Moreover, I have discovered a new family of inhibitors of the anthrax toxin. I am currently in charge of the MASSIV project (ANR-17-CE12-0009, 2018-2021) assessing the impact of alternative splicing on protein structures in evolution. We have developed a couple of efficient methods to assess the evolutionary conservation of splice variants, trace their origin and predict their 3D structures. More details on the Analytical Genomics team website and on the MASSIV repo.