BIS2 co-evolution analysis of HCV envelope glycoproteins
Here we provide the files used and produced in our co-evolution analysis
performed on the envelope glycoproteins E1 and E2 of the Hepatitis C Virus (HCV).
Each folder contains the results of the co-evolution analysis performed with
BIS2:
⚠ Note that the order of the clusters in the article (see below) and in the files provided in this webpage might differ.
Please be aware of this when referring to cluster's IDs.
Contacts
For questions, comments, or suggestions on BIS/BIS2 co-evolution analysis, feel free to contact Alessandra Carbone
or Francesca Nadalin.
For questions, comments, or suggestions regarding HCV biology, feel free to contact Dimitri Lavillette
or Florian Douam.
References
The results reported in this webpage are described in the following article:
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F.Douam, F.Fusil, M.Enguehard, L.Dib, F.Nadalin, L.Schwaller, G.Hrebikova, J.Mancip, L.Mailly, R.Montserret, Q.Ding, C.Maisse, E.Carlot, K.Xu, E.Verhoeyen, T.Baumert, A.Carbone*, FL.Cosset*, D.Lavillette*.
A protein coevolution method designed for conserved sequences uncovers critical features of the original HCV fusion mechanism and provides molecular basis for the design of effective antiviral strategies.
PLoS Pathogens, 2018.
The description of BIS/BIS2 co-evolution method can be found in the following articles:
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F. Oteri, F. Nadalin, R. Champeimont, A. Carbone,
BIS2Analyzer: a server for co-evolution analysis of conserved protein families,
Nucleic Acids Research, 45(W1): W307–W314, 2017.
⇨ to the webserver
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L. Dib, A. Carbone.
Protein fragments: functional and structural roles of their coevolution networks,
PLoS ONE, 7(11): e48124, 2012.
Last Update October 2017