f Elodie Laine's webpage

Elodie Laine

Full Professor in Computational Biology and Artificial Intelligence. Laboratory of Computational and Quantitative Biology, IBPS, Sorbonne Université.

Accreditation to supervise research (2020) from Sorbonne Université. Young Researcher grant (2018-2021, MASSIV project) from the French National Research Agency. Postdoc (2009-2012) at the Laboratory of Biology and Applied Pharmacology, Ecole Normale Supérieure de Cachan. PhD in Life Sciences (2006-2009) from Sorbonne Université, Structural Bioinformatics Unit, Institut Pasteur. See my resume.

Digest

In a nutshell

How do proteins fold, move, and associate? How did they evolve? What are the mechanisms responsible for their misfunction? How can computational methods guide biological intervention and the design of better treatments? These questions are at the core of my research. To address them, I have developed a multidisciplinary scientific approach at the interface of biology, computer science, mathematics, and physics.

I have contributed interpretable and scalable methods for assessing protein diversity in evolution, describing protein functional states and motions, predicting protein interfaces and binding partners, and predicting protein mutational landscapes.

I have co-created with Anne Lopes (U. Paris-Saclay, France) an innovative cross-university collaborative course immersing Masters students into the research ecosystem with project-based learning, flipped classrooms, and "coopetition". We published an educational article. I coordinated the implementation of the initiative at the European level with colleagues from the 4EU+ alliance.

Team

Lab and collab

Marina Abakarova

PhD student. Large-scale assessment of the impact of protein sequence variations on ageing using Drosophila melanogaster. Funded by the ANR.

Louis Carrel-Billiard

PhD student. Charting proteoform diversity across 800 million years of evolution. Funded by the ERC.

Valentin Lombard

PhD student. Geometric deep manifold learning combined with Natural Language Processing for protein movies. SCAI doctoral grant.

Julien Nguyen Van

PhD student. Deciphering the complexity of proteoform interactions with evolutionary- and physically-informed protein language models. Funded by the ERC.

Michael Rera

CNRS Researcher at the Interdisciplinary Research Centre (France). Ageing and natural death, Drosophila. Co-advises M. Abakarova.

Sergei Grudinin

CNRS Researcher at Laboratoire Jean Kuntzmann (France). Macromolecular structures and interactions, AI methods for graph learning. Co-advises V. Lombard.

Hugues Richard

Researcher at the Robert Koch Institute (Germany). high-throughput sequencing data, especially transcriptome (RNA-Seq) data and statistical modelling. Co-advised several Post-doc and students, MASSIV project.

Alessandra Carbone

Professor at Sorbonne Université (SU), Head of the Laboratory of Computational and Quantitative Biology (LCQB, France). Co-advised 1 Post-doctoral fellow and 4 PhD students on protein interactions and protein mutational landscapes.
Béatrice Durand (SU, France) - Wnt signaling, 20K funding from Institute of Biology Paris-Seine, 2023-2024.Mathilde Garcia (SU, France) - Co-translational mechanisms, 6K from SU System Biology Network, 2017.Burkhard Rost (TUM, Germany) - Protein mutational landscapes.
Community efforts - CASP (Zoom), CAPRI, Elixir 3D Bioinfo, ML4NGP, ERGA, LEGO, MASIM.

We are hiring!

We are looking for highly talented and motivated PhDs and Post-doctoral fellows, with backgrounds in applied mathematics, machine learning, algorithms for high-throughput sequencing data, structural bioinformatics and evolutionary biology.

Get in touch!

Publications

Full list here

Alignment-based protein mutational landscape prediction: doing more with less

M. Abakarova, C. Marquet, M. Rera, B. Rost, and E. Laine* (2023) Genome Biology and Evolution View details »

Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein import

S. Nashed, H. El Barbry, M. Benchouaia, A. Dijoux-Maréchal, T. Delaveau, N. Ruiz-Gutierrez, L. Gaulier, D. Tribouillard-Tanvier, G. Chevreux, S. Le Crom, B. Palancade, F. Devaux, E. Laine and M. Garcia* (2023) PLOS Genetics View details »

Mega-scale experimental analysis of protein folding stability in biology and design

K. Tsuboyama, J. Dauparas, J. Chen, E. Laine, Y. Mohseni Behbahani, J. J. Weinstein, N. M. Mangan, S. Ovchinnikov and G. J. Rocklin* (2023) Nature View details »

Building alternative splicing and evolution-aware sequence-structure maps for protein repeats

A. Szatkownik, D.J. Zea, H. Richard* and E. Laine* (2023) J. Struct. Biol. View details »

LEVELNET to visualize, explore, and compare protein–protein interaction networks

Y. Mohseni Behbahani, P. Saighi, F. Corsi, E. Laine* and A. Carbone* (2023) Proteomics. View details »

Software

Try them out

  • All
  • Diversity
  • Interactions
  • Mutations
  • Motions

VespaG

Which mutations impact protein function?

C. Marquet, J. Schlensok, M. Abakarova, B. Rost, and E. Laine* (2024) Submitted

DANCE

From sparse static structures to movies!

V. Lombard, S. Grudinin* and E. Laine* (2024) Submitted

ASPRING

How are protein repeats used in evolution?

A. Szatkownik, D.J. Zea, H. Richard* and E. Laine* (2023)

DLA-Mutation

Which mutations impact binding strength?

Y. Mohseni Behbahani, E. Laine* and A. Carbone* (2023) Bioinformatics.

LEVELNET

Diving into protein interaction networks

Y. Mohseni Behbahani, P. Saighi, F. Corsi, E. Laine* and A. Carbone* (2023) Proteomics.

DLA-Ranker

Which conformations are acceptable?

Y. Mohseni Behbahani, S. Crouzet, E. Laine* and A. Carbone* (2022) Bioinformatics.

ASES [Video]

What does protein diversity look like?

D.J. Zea, H. Richard*, and E. Laine* (2022) Bioinformatics.

ThorAxe [Video]

Which versions of my favourite protein are conserved in evolution?

D.J. Zea, S. Laskina, A. Baudin, H. Richard*, and E. Laine* (2021) Genome Research.

PhyloSofS

Where does this proteoform originate from?

A. Ait-Hamlat, D.J. Zea, A. Labeeuw, L. Polit, H. Richard*, and E. Laine* (2021) J. Mol. Biol.

HOPMA

More freedom to the proteins!

E. Laine* and S. Grudinin* (2021) J. Phys. Chem. B

NOLB [Video]

How does my favourite protein move?

S. Grudinin+, E. Laine+, and A. Hoffmann (2020) Biophys. J. A. Hoffmann and S. Grudinin (2017) J. Chem. Th. Comput.

GEMME [Cover]

Is this mutation deleterious?

E. Laine*, Y. Karami and A. Carbone*. (2019) Mol. Biol. Evol.

JET2DNA

Where are the DNA-binding sites on that protein?

F. Corsi, R. Lavery, E. Laine* and A. Carbone*. (2020) PLoS Comput. Biol.

dynJET2

Through which sites does my favourite protein bind to its partners?

C. Dequeker, E. Laine* and A. Carbone* (2019) Proteins.

COMMA2

Is this mutation deleterious?

Y. Karami, T. Bitard-Feildel, E. Laine* and A. Carbone* (2018) Scientific Reports. Y. Karami, E. Laine* and A. Carbone* (2015) BMC Bioinformatics.

INTBuilder

What residues are found at the interfaces of docked complexes?

C. Dequeker, E. Laine* and A. Carbone* (2017) J. Chem. Inf. Model.

JET2Viewer

Which interfaces with which properties?

H.Ripoche+, E. Laine+, N. Ceres and A. Carbone (2017) Nucl. Acids Res. E. Laine* and A. Carbone* (2015) PLoS Comput. Biol. S. Engelen, L.A. Trojan, S. Sacquin-Mora, R. Lavery, and A. Carbone (2009) PLoS Comput. Biol.

MONETA

How does information propagate through this protein structure?

A. Allain, I. C. de Beauchêne, F. Langenfeld, Y. Guarracino, E. Laine and L. Tchertanov (2014) Faraday discussions. E. Laine, C. Auclair and L. Tchertanov. (2012) PLoS Comput. Biol.

Conferences

Scientific events and courses

LEGO at JOBIM 2024

Half-day meeting on Machine Learning for Genomics and Mini-Symposium shared with StatOmique in Machine Learning and Statistics in Genomics and Metagenomics, June 2024, France.

Deep Learning in Life Sciences

Collaborative course between European Universities, Feb.-June 2024, online. [materials]

LEGO 2023, Machine Learning for Genomics

National working group meeting (90 participants), May 2023, France.

Interplay between AI and mathematical modelling in the post-structural genomics era

International workshop (70 participants), March 2023, France.

AI for Biologists

International summer school (20 students), July 2022, France

New directions of AI in structural biology

International workshop (35 participants), August 2021, France.

Integrative structural modeling in the era of big data and artificial intelligence

Mini-symposium at the French Society for Bioinformatics annual meeting (80 participants), July 2021, online.

Meet-4EU+ Symposium

International symposium mixing education and research (100 participants), January 2021, online.

Noncanonical amino acids (ncAAs): tools for biological and biophysical investigations

International symposium (100 participants), October 2019, France.

Formal methods in the eyes of biological data

Symposium at the French Society for Applied Mathematics meeting (35 participants), June 2017, France.

Evolution of alternative splicing

International symposium at the Society for Molecular Biology and Evolution annual congress, (70 participants), July 2015, Austria

Communications for the general public

realized by La Bande Destinée (2019)

What can proteins tell us?

Contact

Get in touch

Location:

LCQB, UMR 7238
IBPS, CNRS - Sorbonne Université
Jussieu campus – Building C, 4th floor
7-9, quai Saint-Bernard
75005 Paris, FRANCE