Associate Professor in Computational Biology and Artificial Intelligence. Laboratory of Computational and Quantitative Biology, Sorbonne Université.
- Head of the PROMISE project, 2023-2028, Consolidator Grant from the European Research Council. Check our first and second currently open Post-Doc positions!
- Junior member of the institut Universitaire de France, 2023-2028.
Accreditation to supervise research (2020) from Sorbonne Université. Young Researcher grant (2018-2021, MASSIV project) from the French National Research Agency. Postdoc (2009-2012) at the Laboratory of Biology and Applied Pharmacology, Ecole Normale Supérieure de Cachan. PhD in Life Sciences (2006-2009) from Sorbonne Université, Structural Bioinformatics Unit, Institut Pasteur. See my resume.
In a nutshell
How do proteins fold, move, and associate? How did they evolve? What are the mechanisms responsible for their misfunction? How can computational methods guide biological intervention and the design of better treatments? These questions are at the core of my research. To address them, I have developed a multidisciplinary scientific approach at the interface of biology, computer science, mathematics, and physics.
I have contributed interpretable and scalable methods for assessing protein diversity in evolution, describing protein functional states and motions, predicting protein interfaces and binding partners, and predicting protein mutational landscapes.
I have co-created with Anne Lopes (U. Paris-Saclay, France) an innovative cross-university collaborative course immersing Masters students into the research ecosystem with project-based learning, flipped classrooms, and "coopetition". We published an educational article. I coordinated the implementation of the initiative at the European level with colleagues from the 4EU+ alliance.
Lab and collab
Marina AbakarovaPhD student. Large-scale assessment of the impact of protein sequence variations on ageing using Drosophila melanogaster. Funded by the ANR.
Michael ReraCNRS Researcher at the Interdisciplinary Research Centre (France). Ageing and natural death, Drosophila. Co-advises M. Abakarova.
Sergei GrudininCNRS Researcher at Laboratoire Jean Kuntzmann (France). Macromolecular structures and interactions, AI methods for graph learning. Co-advises V. Lombard.
Hugues RichardResearcher at the Robert Koch Institute (Germany). high-throughput sequencing data, especially transcriptome (RNA-Seq) data and statistical modelling. Co-advised several Post-doc and students, MASSIV project.
Béatrice Durand (SU, France) - Wnt signaling, 20K funding from Institute of Biology Paris-Seine, 2023-2024.Mathilde Garcia (SU, France) - Co-translational mechanisms, 6K from SU System Biology Network, 2017.Burkhard Rost (TUM, Germany) - Protein mutational landscapes.
Community efforts - CASP (Zoom), CAPRI, Elixir 3D Bioinfo, ML4NGP, ERGA, LEGO, MASIM.
We are hiring!
We are looking for highly talented and motivated Post-doctoral fellows, with backgrounds in applied mathematics, machine learning, algorithms for high-throughput sequencing data, structural bioinformatics and evolutionary biology.Get in touch!
Full list here
M. Abakarova, C. Marquet, M. Rera, B. Rost, and E. Laine* (2023) Genome Biology and Evolution View details »
Functional mapping of N-terminal residues in the yeast proteome uncovers novel determinants for mitochondrial protein import
S. Nashed, H. El Barbry, M. Benchouaia, A. Dijoux-Maréchal, T. Delaveau, N. Ruiz-Gutierrez, L. Gaulier, D. Tribouillard-Tanvier, G. Chevreux, S. Le Crom, B. Palancade, F. Devaux, E. Laine and M. Garcia* (2023) PLOS Genetics View details »
K. Tsuboyama, J. Dauparas, J. Chen, E. Laine, Y. Mohseni Behbahani, J. J. Weinstein, N. M. Mangan, S. Ovchinnikov and G. J. Rocklin* (2023) Nature View details »
A. Szatkownik, D.J. Zea, H. Richard* and E. Laine* (2023) J. Struct. Biol. View details »
Y. Mohseni Behbahani, P. Saighi, F. Corsi, E. Laine* and A. Carbone* (2023) Proteomics. View details »
Deep Local Analysis deconstructs protein–protein interfaces and accurately estimates binding affinity changes upon mutation
Y. Mohseni Behbahani, E. Laine*, and A. Carbone* (2023) Bioinformatics 39:i544–i552. View details »
Try them out
How are protein repeats used in evolution?A. Szatkownik, D.J. Zea, H. Richard* and E. Laine* (2023)
Which mutations impact binding strength?Y. Mohseni Behbahani, E. Laine* and A. Carbone* (2023) Bioinformatics.
Diving into protein interaction networksY. Mohseni Behbahani, P. Saighi, F. Corsi, E. Laine* and A. Carbone* (2023) Proteomics.
Which conformations are acceptable?Y. Mohseni Behbahani, S. Crouzet, E. Laine* and A. Carbone* (2022) Bioinformatics.
What does protein diversity look like?D.J. Zea, H. Richard*, and E. Laine* (2022) Bioinformatics.
Which versions of my favourite protein are conserved in evolution?D.J. Zea, S. Laskina, A. Baudin, H. Richard*, and E. Laine* (2021) Genome Research.
Where does this proteoform originate from?A. Ait-Hamlat, D.J. Zea, A. Labeeuw, L. Polit, H. Richard*, and E. Laine* (2021) J. Mol. Biol.
More freedom to the proteins!E. Laine* and S. Grudinin* (2021) J. Phys. Chem. B
How does my favourite protein move?S. Grudinin+, E. Laine+, and A. Hoffmann (2020) Biophys. J. A. Hoffmann and S. Grudinin (2017) J. Chem. Th. Comput.
Is this mutation deleterious?E. Laine*, Y. Karami and A. Carbone*. (2019) Mol. Biol. Evol.
Where are the DNA-binding sites on that protein?F. Corsi, R. Lavery, E. Laine* and A. Carbone*. (2020) PLoS Comput. Biol.
Through which sites does my favourite protein bind to its partners?C. Dequeker, E. Laine* and A. Carbone* (2019) Proteins.
Is this mutation deleterious?Y. Karami, T. Bitard-Feildel, E. Laine* and A. Carbone* (2018) Scientific Reports. Y. Karami, E. Laine* and A. Carbone* (2015) BMC Bioinformatics.
What residues are found at the interfaces of docked complexes?C. Dequeker, E. Laine* and A. Carbone* (2017) J. Chem. Inf. Model.
Which interfaces with which properties?H.Ripoche+, E. Laine+, N. Ceres and A. Carbone (2017) Nucl. Acids Res. E. Laine* and A. Carbone* (2015) PLoS Comput. Biol. S. Engelen, L.A. Trojan, S. Sacquin-Mora, R. Lavery, and A. Carbone (2009) PLoS Comput. Biol.
How does information propagate through this protein structure?A. Allain, I. C. de Beauchêne, F. Langenfeld, Y. Guarracino, E. Laine and L. Tchertanov (2014) Faraday discussions. E. Laine, C. Auclair and L. Tchertanov. (2012) PLoS Comput. Biol.
Organisation of scientific events
National working group meeting (90 participants), May 2023, France.
International workshop (70 participants), March 2023, France.
International summer school (20 students), July 2022, France
International workshop (35 participants), August 2021, France.
Mini-symposium at the French Society for Bioinformatics annual meeting (80 participants), July 2021, online.
International symposium mixing education and research (100 participants), January 2021, online.
International symposium (100 participants), October 2019, France.
Symposium at the French Society for Applied Mathematics meeting (35 participants), June 2017, France.
Evolution of alternative splicing
International symposium at the Society for Molecular Biology and Evolution annual congress, (70 participants), July 2015, Austria
Participation in videos and articles for the general public
realized by La Bande Destinée (2019)What can proteinn tell us?
Sciences et Vie
2021/08, 2021/11 (Junior)
Data Analytics Post
Get in touch
LCQB, UMR 7238
IBPS, CNRS - Sorbonne Université
Jussieu campus – Building C, 4th floor
7-9, quai Saint-Bernard
75005 Paris, FRANCE