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Scent of a worm

Thursday, May 20, 2021 - 11:00
Mirko Francesconi
Participer à la réunion Zoom ID de réunion : 892 640 6558 Code secret : 7mdSKr
Laboratory of Biology and Modeling of the Cell, ENS de Lyon

Genetically identical individuals growing in the same environment often show substantial phenotypic variation. The reasons for this phenotypic variation are usually unknown. We start from genome wide expression profiling on genetically identical C. elegans roundworms to characterize molecular differences, understand their phenotypic impact and infer the mechanisms that generate such variation. I will show how using this strategy we previously found maternal age to be an important determinant of phenotypic variation with changes in maternal provisioning of yolk to the embryo explain some of the observed phenotypic differences. Then I will show we have now found the ‘smell’ of the worms (i.e pheromones) - which is perceived by neurons – also induces important phenotypic variation generating an inherited memory that alters germline development and minimum generation time in the progeny of exposed worms. 

Interdisciplinary Seminar

Open Positions