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Circuits and programmable self-assembling DNA structures.

TitleCircuits and programmable self-assembling DNA structures.
Publication TypeJournal Article
Year of Publication2002
AuthorsCarbone, A, Seeman, NC
JournalProc Natl Acad Sci U S A
Volume99
Issue20
Pagination12577-82
Date Published2002 Oct 1
ISSN0027-8424
KeywordsAlgorithms, DNA, Models, Theoretical, Nucleic Acid Conformation, Software
Abstract

Self-assembly is beginning to be seen as a practical vehicle for computation. We investigate how basic ideas on tiling can be applied to the assembly and evaluation of circuits. We suggest that these procedures can be realized on the molecular scale through the medium of self-assembled DNA tiles. One layer of self-assembled DNA tiles will be used as the program or circuit that leads to the computation of a particular Boolean expression. This layer templates the assembly of tiles, and their associations then lead to the actual evaluation involving the input data. We describe DNA motifs that can be used for this purpose; we show how the template layer can be programmed, in much the way that a general-purpose computer can run programs for a variety of applications. The molecular system that we describe is fundamentally a pair of two-dimensional layers, but it seems possible to extend this system to multiple layers.

DOI10.1073/pnas.202418299
Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID12232051
PubMed Central IDPMC130502
Grant ListGM-29554 / GM / NIGMS NIH HHS / United States