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Genetic Networks

June 22, 2018

Pierre Louis Blaiseau of the Genetic Networks team recently published « Monod and the phenomenon of diauxie » in the Bulletin d’Histoire et d’Epistémologie des Sciences de la vie. This article described a part of the scientific activity of the Jacques Monod until then neglected by the historians: its interest during all its career for the mechanisms of enzymatic inhibition. Besides, it showed that, contrary to the standard narratives, the phenomenon of « diauxie » (double growth) was discovered by Monod during his thesis and not by the previous Frederic Diénert’s work

July 5, 2016

F. Devaux's team published one of the first ChIP-seq-based description of the transcriptional regulatory networks in the pathogenic yeast Candida glabrata. This work, which was performed in collaboration with J-M. Camadro and G. Lelandais from the Jacques Monod Institute and with the NGS platform directed by S. Le Crom, is the first publication from a larger ANR project aiming at a comprehensive description of stress response regulatory networks in this emerging human pathogen.

March 10, 2015

Nitric oxyde oxydases are enzymes which contributes to the resistance of pathogenic microbes to the innate immune system by detoxifying nitric oxide. "The genetic networks" team identified a new regulator of the expression of nitric oxydases in fungi and deciphered its functioning and evolution in different pathogenic and non-pathogenic yeast species. 

http://www.ncbi.nlm.nih.gov/pubmed/25732006

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