The Laboratory of Computational and Quantitative Biology (LCQB), headed by A. Carbone, is an interdisciplinary laboratory working at the interface between biology and quantitative sciences. It is built to promote a balanced interaction of theoretical and experimental approaches in biology and to foster the definition of new experimental questions, data analysis and modeling of biological phenomena. Our projects address questions on biological structures and processes through the gathering of experimental measures, the in silico generation of new biological data that remain inaccessible to experiments today (modeling of biological systems), the development of statistical methods for data analysis, and the conception of original algorithms aimed to predictions. The lab is supported by the CNRS and the University "Sorbonne Université".

News

July 15-August 8, 2014

A.Carbone and E.Laine, from the Analytical Genomics Team, organize the ICS Summer School 2014 "Scientific Trends at the Interfaces - Bioinformatics and Scientific Visualization". Information on the school can be downloaded here.

March 28, 2014

The Biology of Genomes team participated to the complete design and synthesis of the first eukaryotic synthetic chromosome. We compared replication dynamics of synthetic and native chromosome III and saw few dramatic changes in spite of several autonomously replicating sequences having been deleted.

Total Synthesis of a Functional Designer Eukaryotic Chromosome. Annaluru, Muller et al., Science (2014) DOI:10.1126/science.1249252

February 8, 2014

A World Community Grid Lecture Series webcast describing the work done by the team and its collaborators on protein-protein interactions, within the framework of the "Help Cure Muscular Dystrophy" project can be found here.

January 23-24, 2014

Hugues Richard co-organizes the 10th edition of the workshop: Statistical Methods for (Post-) Genomics Data (SMPGD). 

The Laboratory Genomics of Microorganisms will hosts the meeting at the UPMC main campus, Paris, France.

December 24, 2013

Gherardi M, Mandrà S, Bassetti B, Cosentino Lagomarsino M, "Evidence for soft bounds in Ubuntu package sizes and mammalian body masses"

Proc Natl Acad Sci USA. 2013 Dec 24;110(52):21054-8.

December 12-13, 2013

Marco Cosentino Lagomarsino co-organizes the 2nd edition of Quantitative Methods in Gene Regulation

December 3, 2013

Vittore Scolari (Genomic Physics group) and Alice Coucke (Statistical Genomics team) co-organize the 1th edition of the conference:
Paris Biological Physics Community Day 2013 
The conference will be hosted at Centre Culturel Irlandais in Paris.

October 28, 2013

The Analytical Genomics team releases the complete cross docking data of Mintseris Benchmark 2.0.

The analysis will are available in the article:

Anne Lopes,  Sophie Sacquin-Mora, Viktoriya Dimitrova, Elodie Laine, Yann Ponty, Alessandra Carbone. Protein-Protein Interactions in a Crowded Environment: An Analysis via Cross-Docking Simulations and Evolutionary Information. PLOS computational Biology (2013).

The dataset of protein-protein interactions was produced with over 7 months of computations on World Community Grid and with the help of thousands of internautes providing their computer time to dock about 300000 conformations per protein pair in the set of 28224 possible pairs in the Mintseris dataset.

October 10-11, 2013

The 3rd Cross Disciplinary Genomics meeting "Biological networks: current and future challenges" will be held at UPMC, in the Jussieu Campus.

There is no participation fee but registration is required.

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